Medical therapy of gliomas
نویسندگان
چکیده
منابع مشابه
Gene Therapy for Malignant Gliomas
Retroviruses are enveloped RNA viruses that possess the ability to integrate into the host cell genome by transcribing DNA from their RNA template via viral reverse transcriptase. The transcribed viral DNA is then integrated into the host cell genome nonspecifically. There is relative specificity for tumors because, except for lentiviruses, retroviral DNA preferentially integrates into the geno...
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To further develop gene therapy for patients with glioblastomas, an experimental gene therapy protocol was established comprising a series of imaging parameters for (i) noninvasive assessment of viable target tissue followed by (ii) targeted application of herpes simplex virus type 1 (HSV-1) amplicon vectors and (iii) quantification of treatment effects by imaging. We show that viable target ti...
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The prognosis of patients with malignant glioma is poor in spite of multimodal treatment approaches consisting of neurosurgery, radiochemotherapy and maintenance chemotherapy. Among innovative treatment strategies like targeted therapy, antiangiogenesis and gene therapy approaches, immunotherapy emerges as a meaningful and feasible treatment approach for inducing long-term survival in at least ...
متن کاملImaging-guided gene therapy of experimental gliomas
To further develop gene therapy for patients with glioblastomas, an experimental gene therapy protocol was established comprising a series of imaging parameters for (i) noninvasive assessment of viable target tissue followed by (ii) targeted application of herpes simplex virus type 1 (HSV-1) amplicon vectors and (iii) quantification of treatment effects by imaging. We show that viable target ti...
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Cancer is a disease of a series of genes. Thus, theoretically, brain tumors could be treated by targeting their fundamental molecular defects. Currently, most of the approved clinical protocols for gene therapy involve cancer patients. Several of these protocols are designed to improve the treatment of brain tumors. In this brief report, we analyze the rationale, advantages, and disadvantages o...
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ژورنال
عنوان ژورنال: Journal of Neuro-Oncology
سال: 2014
ISSN: 0167-594X,1573-7373
DOI: 10.1007/s11060-014-1495-1